Exjobbsförslag från företag
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Förslaget inkom 2011-04-28
Identification of the arthritis regulating gene in APLEC
OBS! ANSÖKNINGSTIDEN FÖR DETTA EXJOBB HAR LÖPT UT.
Previous genetic studies in experimental arthritis have identified a complex of C-type lectin receptors that are expressed on antigen presenting cells to be regulating arthritis development in the rat. The complex, called APLEC, contains 7 genes and is ~500 mega bases in size. In order to identify the disease regulating gene in the complex a number of already established APLEC recombinant congenic strains will initially be tested for in vivo arthritis development. Following disease development evaluation the recombinants will be assessed for quantitative expression of the APLEC encoded genes to ascertain the expression levels associated to disease development. The APLEC recombinants will also be analysed for characteristic cellular immune phenotypes. Methods: The student will use qRT-PCR to quantify the expression levels of the 7 APLEC genes before and after arthritis induction in the APLEC recombinants. Flowcytometry will be used to identify cellular phenotypes associated with disease regulation in the APLEC complex.
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