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Computational mapping of protease binding sites
Proteases represent around 2% of the proteins in all organisms and regulate many vital functions that are of medical interest. Primary sequence data for some 800 proteases has been made available through the human genome project but is accompanied by very limited structural information.
The aim of the project is to explore computational methods for mapping the relationship between the binding sites of different members of the protease family by combining primary sequence data with structural information from family representatives.
The information generated will have several uses directly relevant to Medivir¿s research programme. Firstly, it can be used to identify related targets to be used in selectivity assays. Secondly, it will aid in the identification of novel targets. Thirdly, it can be used to guide new chemistry by indicating which molecular properites that are complementary to a given binding site.
Medivir is an innovative, specialized company active in drug research and development. The company pursues rational drug research based on detailed knowledge of gene and the gene products encoding proteases and polymerases. These enzymes represent a broad diversity and regulate life-sustaining functions in humans and micro organisms. Research is directed towards developing compounds into new drugs that suppress and regulate the function of proteases and polymerases in various medical disorders.
The successful candidate will have a strong interest in computational biology, bioinformatics and structural biology. It is important that the candidate enjoys working with computers and should preferably have some programming experience. A keen interest in organic chemistry is an advantage as the project ultimately aims at developing new drugs.
Informationen om uppsatsförslag är hämtad från Nationella Exjobb-poolen.